Work

Comportamiento de anticuerpos IgG anti-SARS-CoV-2 en trabajadores de salud pre y posvacunación en un centro oncológico de Guatemala

Year: 2022

Type: article

Abstract: Introduction: The study of anti-SARS-CoV-2 IgG antibodies allows asymptomatic individuals with COVID-19 to be identified, and post-infection and post-vaccination immunity status to be evaluated.Objective: To know the behavior of anti-SARS-CoV-2 IgG antibodies before and after vaccination in workers of a cancer center.Methods: Prior to the application of the vaccine, the presence of anti-SARS-CoV-2 IgG antibodies (n = 171) was analyzed by evaluating anti-N IgG antibodies; post-vaccination, after receiving the second dose, anti-S IgG antibodies were evaluated (n = 60).Results: Prior to vaccination, IgG antibodies were present in 18.71% of participants; they were detected in 65.22% of those with prior history of COVID-19 diagnosis and in 11.49% of those without it.The positions with the highest prevalence were nurses (28.26%), paramedics (27.59%) and administrative workers (27.78%), p < 0.01.Anosmia, ageusia and chest tightness were associated with the presence of IgG (p < 0.05).Post-vaccination, all participants developed IgG antibodies; people with a previous COVID-19 diagnosis had higher titers: 10,277 vs. 6,819 AU/mL, p < 0.001.Conclusions: The study of anti-SARS-CoV-2 IgG antibodies allowed asymptomatic health workers to be identified.A high percentage of participants with prior COVID-19 diagnosis had antibodies.All participants developed IgG antibodies after vaccination, with higher titers being identified in those with previous infection.

Source: Gaceta Médica de México

DOI: 10.24875/gmm.21000674