Work

2‐O‐Acetyl‐3,4,5,6‐tetra‐O‐benzyl‐ d ‐myo‐inosityl diphenylphosphate: A new useful intermediate to inositol phosphate and phospholipids

Year: 2022

Type: article

Abstract: Inositol phosphates and inositol phospholipids are ubiquitous in biochemistry and play a central role in cell signaling and regulation events. For this reason, their synthesis has attracted widespread interest. This paper describes the preparation of a new optically active inositol phosphate derivative, 2-O-acetyl-3,4,5,6-tetra-O-benzyl-d-myo-inosityl diphenylphosphate (6), and its characterization by spectroscopic methods. Compound (6) represents a useful intermediate for the preparation of inositol phosphate and phospholipids, in particular of glycerophosphoinositol (GPI), a natural anti-inflammatory agent.

Source: Chirality

DOI: 10.1002/chir.23457

Authors: Sara Sangiorgio, Mattia Cambò, Riccardo Semproli, Daniela Ubiali, Giovanna Speranza, Marco Rabuffetti

Institutions: University of Milan, University of Pavia

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,550

Funder: Fondazione Cariplo