An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes
Year: 2022
Type: article
Study design: Observational Study
Source: Cancer Cell
Authors: Abhinav Jaiswal, Akanksha Verma, Ruth Dannenfelser, Marit Melssen, Itay Tirosh, Benjamin Izar, Tae-Gyun Kim, Christopher J. Nirschl, K. Sanjana P. Devi, Walter C. Olson, Craig L. Slingluff, Victor H. Engelhard, Levi Garraway, Aviv Regev, Kira Minkis, Charles H. Yoon, Olga Troyanskaya, Olivier Elemento, Mayte Suárez-Fariñas, Niroshana Anandasabapathy
Institutions: Weill Cornell Medicine, Princeton University, University of Virginia Medical Center, University of Virginia Cancer Center, University of Virginia, Weizmann Institute of Science, Herbert Irving Comprehensive Cancer Center, Columbia University, Yonsei University, Brigham and Women's Hospital, Harvard University, Broad Institute, Dana-Farber Cancer Institute, Dana-Farber Brigham Cancer Center, Simons Foundation, Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Burroughs Wellcome Fund, Cancer Research Institute, Eli Lilly and Company, AstraZeneca, Merck, Presbyterian Historical Society, Broad Institute, UVA Cancer Center, National Institutes of Health, Johnson and Johnson, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Janssen Pharmaceuticals, West Coast Metabolomics Center, University of California, Davis
Awards: G180033599, G357276490, Dissecting drug resistance in serial uveal melanoma biopsies using integrated, multi-modal single-cell profiling and novel machine learning tools., Dissecting mechanisms of immunotherapy resistance in melanoma patients, Peripheral mechanisms of homeostasis and tolerance through skin dendritic cells, G4820760458, Peripheral immune surveillance and long-lived barrier immunity through T cell DC cross-talk, Fluorescence molecular tomography to study T cell infiltration into tumors, Dermatology Training Grant, Mechanisms of liver metastasis and associated resistance to immunotherapy, University of Virginia Cancer Center Support Grant, Interrogating unique DC adaptations to tissue to promote barrier immunity and tolerance
OpenAlex ID: W4229376972