Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms
Year: 2022
Type: article
Abstract: Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV–vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced Staphylococcus aureus and Klebsiella pneumoniae biofilms formation on adhesive surfaces.
Source: Nanomaterials
DOI: 10.3390/nano12091604
Authors: Dmitriy N. Shurpik, Yulia I. Aleksandrova, Olga A. Mostovaya, Viktoriya A. Nazmutdinova, Regina E. Tazieva, Fadis F. Murzakhanov, Marat R. Gafurov, Pavel V. Zelenikhin, Evgenia V. Subakaeva, Evgenia A. Sokolova, Alexander V. Gerasimov, Vadim V. Gorodov, Daut R. Islamov, Peter J. Cragg, Ivan I. Stoikov
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,513
Award: G5263414418
OpenAlex ID: W4229456599