Work

Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging

Year: 2014

Type: preprint

Abstract: To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.

DOI: 10.7287/peerj.preprints.464v3

Authors: Stephanie B Stewart, Jonathan M Koller, Meghan C Campbell, Joel S Perlmutter, Kevin J Black

Institution: Washington University in St. Louis

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4231471069

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