Work

Molecular Alterations in Epidermal Growth Factor Receptors as Potential Predictors of Invasion in Complete Hydatidiform Moles (CHM)

Year: 2012

Type: article

Abstract: Molecular alterations in Epidermal growth factor receptor (EGFR) were investigated for the first time in molar placenta using protein expression, activation status, differential amplification status and mutational analysis. Invasive lesions showed upregulation of internal domain and downregulation of external domain with concomitantly high gene amplification and phosphorylation. Mutations distributed across different exons in non-invasive cases in contrast to single mutations restricted to exons 4 and 6 in invasive cases displayed a strong correlation to overexpression and phosphorylation status suggesting that higher copies of EGFR gene and mutations in exon 4&6 influence the invasive capacity of trophoblasts and can be used as a biomarker of invasion.

Source: Disease Markers

DOI: 10.1155/2012/653725

Authors: Jemima Jacob, Prabha Balaram

Institutions: Regional Cancer Center, Thiruvananthapuram, Universiti Sains Malaysia

Language: English

Topic: Gestational Trophoblastic Disease Studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,550