A Hair Growth-Enhancing Component of Hydrolysate of Human Placenta: In vitro and In vivo Assessments
Year: 2015
Type: article
Abstract: Background: Human placenta hydrolysate (HPH) has been used to promote wound healing, for its anti-aging effects, and, more recently, for hair growth.However, the main component(s) of HPH that induce hair growth remain unknown.Aim: To test the hypothesis that IGF-1, a component of HPH, promotes hair growth and to evaluate the possible mechanism.Methods: We examined the effects of IGF-1 and an amino acid mixture on the cell viability of human dermal papilla cells and on GSK-3β and beta-catenin signaling pathways.We also examined the effects of IGF-1 on the development of hair follicles in C57BL6/J mice using hematoxylin and eosin staining.Results: We found that IGF-1 modulated hair growth signal.Specifically, it increased both the number and size of hair follicles in groups treated with IGF-1 and with the amino acid mixture.
Language: English
Topic: Hair Growth and Disorders
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4239486617