Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule Release
Year: 2016
Type: article
Abstract: (Cell Reports 15, 9–18; April 5, 2016) In the version of this paper originally published online on March 24, 2016 the author name, “Veronica Candi” was inadvertently transposed. This has been corrected online, and the authors apologize for the error. Human Cytotoxic T Lymphocytes Form Dysfunctional Immune Synapses with B Cells Characterized by Non-Polarized Lytic Granule ReleaseKabanova et al.Cell ReportsMarch 24, 2016In BriefKabanova et al. provide evidence that resting human B cells escape killing by cytotoxic T cells (CTLs) by inducing non-polarized exocytosis of their lytic granules. Non-polarized degranulation is associated with an altered formation of the immune synapse and may represent a mechanism that allows B cell malignancies to evade CTLs. Full-Text PDF Open Access
Source: Cell Reports
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,620
OpenAlex ID: W4240634858