Year: 2006
Type: conference-abstract
Abstract: Many applications in science and engineering require the controlled release of small quantities of molecules or nanoparticle conjugates.Current approaches include microfluidic arrays, encapsulated polymers, and microfabricated reservoirs with dissolvable lids.Electrochemical desorption of self-assembled monolayers offers a powerful tool for the programmed release of immobilized molecules (e.g.drugs, peptides, proteins, DNA, and viruses) and nanoparticles from an electrode surface.Since the molecules or particles are anchored to a surface in a monolayer, patterning techniques can be used to provide spatial control of the release of one or more molecules or particles, and of very small quantities.Furthermore, the electrodes can be regenerated and hence can be used for multiple release cycles.We expect this technique to find application in fields such as controlled drug release devices, gene expression platforms, programmable DNA/protein arrays, protein purification systems, and micro-reactors.Here we demonstrate the controlled release and regeneration of proteins and nanoparticles tethered to gold electrode arrays through a thiol linkage.
Source: ECS Meeting Abstracts
Authors: P. C. Searson, Prashant Mali
Institution: Johns Hopkins University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4241305145