Protective effect of Moringa peregrina seed oil against doxorubicin-induced hepatotoxicity in male mice
Year: 2016
Type: article
Abstract: The present study aimed to illustrate the histopathological and immunohistochemical changes in the liver of mice exposed to anticancer drug, doxorubicin (DOX), and to evaluate the possible protective role of Moringa peregrina seed oil.Thirty two mature male mice were randomly divided into four groups.One group served as a control, the other was given a dose of M. peregrine at the rate of 150 mg/kg body weight, third group was DOX treated, and fourth was DOX plus M. peregrina treated.Histopathological examination of liver sections showed that DOX caused disturbance in hepatic cords, hepatocytes degeneration, inflammation, necrotic areas, vacuolation and dilation of the blood sinusoids.Doxorubicin treated animals demonstrated a positive reaction to Caspase-3 in hepatocytes as compared with controls.Administration of M. peregrina seed oil plus doxorubicin showed reduction in caspase-3 immunoreactivity and apoptotic index induced by DOX.Treatment with M. peregrina seed oil 150 mg/kg body weight reduced the damage caused by DOX in the liver.
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4242065005