Successful Treatment Of Homozygous Familial Hypercholesterolemia Using Cascade Filtration Plasmapheresis
Year: 2012
Type: article
Abstract: Objective: The aim of this study was to report the efficacy of low-density lipoprotein cholesterol (LDL-C) apheresis using a cascade filtration system in pediatric patients with homozygous familial hypercholesterolemia (FH), and to clarify the associated adverse effects and difficulties.Material and Methods: LDL-C apheresis using a cascade filtration system was performed in 3 pediatric patients with homozygous FH; in total, 120 apheresis sessions were performed.Results: Cascade filtration therapy significantly reduced the mean LDL-C values from 418 ± 62 mg/dL to 145 ± 43 mg/ dL (p= 0.011).We observed an acute mean reduction in the plasma level of total cholesterol (57.9%),LDL-C (70.8%), and high-density lipoprotein cholesterol (HDL-C) (40.7%).Treatments were well tolerated.The most frequent clinical adverse effects were hypotension in 3 sessions (2.5%), chills (1.7%) in 2 sessions, and nausea/vomiting in 3 sessions (2.5%).Conclusion: Our experience using the cascade filtration system with 3 patients included good clinical outcomes and laboratory findings, safe usage, and minor adverse effects and technical problems.
Source: Turkish Journal of Hematology
Institution: Erciyes University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4242775475