Work

Serum paraoxonase-1 activity in Egyptian premenopausal women with metabolic syndrome and its relation with recurrent pre-eclampsia risk

Year: 2018

Type: article

Abstract: Background: Association of paraoxonase-1 (PON-1) with the metabolic syndrome (MS) and recurrent pre-eclampsia has not been previously investigated among Egyptian premenopausal women.Pre-eclampsia is a multisystem disorder and its etiopathogenesis has not yet been fully understood.Aim: The aim of the study is to investigate serum PON-1 activity in Egyptian women with MS and assess its potential link with the incidence of recurrent pre-eclampsia. Method:The study group consisted of 60 premenopausal women with MS and 60 healthy controls.In the MS group, 26 patients had past history of recurrent pre-eclampsia.The enzymatic activity of serum PON-1 was measured by spectrophotometer.Serum lipids were measured by enzymatic colorimetric methods using a Hitachi auto-analyzer.Results: MS cases with and without recurrent pre-eclampsia showed significantly reduced PON-1 activity compared to healthy controls.Significant negative correlations were observed between PON-1 levels and BMI, SBP, DBP, serum total cholesterol, TG and LDL-C and positive correlation with HDL-C in MS cases either with or without recurrent pre-eclampsia.In addition, MS cases with history of recurrent pre-eclampsia showed significantly lower levels of PON-1 than those without.Conclusions: Serum PON-1 is significantly reduced in women with MS and might alter their lipid profile.Low PON-1 levels could contribute to the great risk of recurrent pre-eclampsia in MS women.

Source: Journal of Applied Pharmaceutical Science

DOI: 10.7324/japs.2018.8208