Cumulative Incidence of SARS-CoV-2 Infection and Associated Risk Factors Among Frontline Health Care Workers in Paris, France: The SEROCOV Prospective Cohort Study
Year: 2021
Type: preprint
Study design: Observational Study
Abstract: Objective With the COVID-19 pandemic, documenting whether health care workers (HCWs) are at increased risk of SARS-CoV-2 contamination and identifying risk factors is of major concern. Methods In this multicenter prospective cohort study, HCWs from frontline departments were included in March and April 2020 and followed for 3 months. SARS-CoV-2 serology was performed at month 0 (M0), M1, and M3 and RT-PCR in case of symptoms. The primary outcome was laboratory-confirmed SARS-CoV-2 infection at M3. Risk factors of laboratory-confirmed SARS-CoV-2 infection at M3 were identified by multivariate logistic regression. Results Among 1,062 HCWs (median [interquartile range] age, 33 [28-42] years; 758 [71.4%] women; 321 [30.2%] physicians), the cumulative incidence of SARS-CoV-2 infection at M3 was 14.6% (95% confidence interval [CI] [12.5; 16.9]). Risk factors were the working department specialty, with increased risk for intensive care units (odds ratio 1.80, 95%CI [0.38; 8.58]), emergency departments (3.91 [0.83; 18.43]) and infectious diseases departments (4.22 [0.92; 18.28]); active smoking was associated with reduced risk (0.36 [0.21; 0.63]). Age, sex, professional category, number of years of experience in the job or department, and public transportation use were not significantly associated with laboratory-confirmed SARS-CoV-2 infection at M3. Conclusion The rate of SARS-CoV-2 infection in frontline HCWs was 14.6% at the end of the first COVID-19 wave in Paris and occurred mainly early. The study argues for an origin of professional in addition to private life contamination and therefore including HCWs in the first-line vaccination target population. It also highlights that smokers were at lower risk. Trial registration: The study has been registered on ClinicalTrials.gov: NCT04304690 first registered on 11/03/2020.
Source: Research Square
Authors: Pierre Hausfater, David Boutolleau, Karine Lacombe, Alexandra Beurton, Margaux Dumont, Jean-Michel Constantin, Jade Ghosn, Alain Combes, Nicolas Cury, Romain Guedj, Michel Djibré, Rudy Bompard, Sandie Mazerand, Valérie Pourcher, Linda Gimeno, Clemence Marois, Elisa Teyssou, Anne-Geneviève Marcelin, David Hajage, Florence Tubach
Institutions: Sorbonne Université, Pitié-Salpêtrière Hospital, Inserm, Assistance Publique – Hôpitaux de Paris, Institut Pierre Louis d‘Épidémiologie et de Santé Publique, Hôpital Saint-Antoine, Neurophysiologie respiratoire expérimentale et clinique, Université Paris Cité, Hôpital Bichat-Claude-Bernard, Infection, Anti-microbiens, Modélisation, Evolution, Hôpital Armand-Trousseau, Hôpital Tenon
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4248399425