Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression
Year: 2018
Type: article
Abstract: TSC1KO BAL fluid infiltrates.Arrows and arrowheads represent neutrophils and macrophages, respectively.(E) Enhanced interstitial infiltration in TSC1KO lungs.Representative H&E staining of lung thin sections is shown.(F) mRNA levels of Il17a (increased) and Ifng (decreased) in the lungs of TSC1KO mice 5 hours after α-GalCer treatment.(G) Neutrophil numbers in the lungs after S. pneumoniae infection.Ctrl, uninfected; Infect, infected.(H) mRNA levels of indicated cytokines in iNKT cells isolated from lungs after S. pneumoniae infection.*P < 0.05; **P < 0.01; ***P < 0.001, 2-way ANOVA (A); Student's t test (B, C, F-H).Data are representative of 2 or 3 independent experiments with 12 female WT and TSC1KO mice (A), 12 male WT and 15 male TSC1KO mice (A), 4 mice (B, C, F) and 5 mice (G and H) per group in each experiment.Original magnification, ×400 (D); ×200 (E).The authors regret the errors and appreciate the opportunity to correct the article.
DOI: 10.1172/jci120803
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Clinical utilization and investigation of ovarian cancer genome diversity associated with metastasis, resistance to treatment and immune escape, Immune Impact on Cancer Chemoresistance, G2117675313, Investigation of acquired resistance of PD-1 inhibitor with recycle of CART system, Investigation of immune-suppressive dynamism and exploratory research for new treatment strategy for gynecologic cancer
OpenAlex ID: W4249980792