Year: 2020
Type: book-chapter
Abstract: Over the past decade, researchers have designed, synthesized, studied, and applied polyvalent DNA-functionalized gold nanoparticles (DNA-AuNPs) [ 1 ]. These efforts have resulted in a new fundamental understanding of hybrid nanostructures [ 2 ], important and in certain cases commercially viable detection and diagnostic assays [ 3 ], and the ability to program materials assembly through the use of DNA synthons [ 1 , 4 ]. Polyvalent DNA-AuNPs 1578 have several unique properties, such as sharp and elevated melting temperatures [2b], enhanced binding properties [2c] (as compared with free strands of the same sequence), and distance-dependent optical properties [ 5 ]. In agreement with research on polyvalent molecular systems [ 6 ], the high surface DNA density and the ability of the nanoparticles to engage in multidentate interactions are the proposed origin of these unique properties.
Source: Spherical Nucleic Acids
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4251069424