Work

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Year: 2021

Type: preprint

Abstract: Multiple variants of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are constantly reported across the world. B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated P.1 (VOC) and P.2 (VOI). Here we describe an early case of P.1 primary infection in Southern Brazil in late November 2020, soon after the emergence of the variant in Manaus, Northern Brazil. The same patient suffered a reinfection case by another B1.1.28 variant, namely P.2, in March, 2021. Genomic analysis showed genetically significant differences between the viruses recovered in both infections. P.1 lineage at the first episode and P.2 at the reinfection. We also have investigated the circulation of P.1 in the same region by differential RT-qPCR, showing that this was an isolated case of P.1 at the time of detection, whereas the variant disseminated and became prominent from late January 2021 to the end of March 2021.

Source: Research Square

DOI: 10.21203/rs.3.rs-435535/v2