Work

Ascorbate (1g/day) does not help the phagocyte killing defect of X-linked chronic granulomatous disease.

Year: 1983

Type: article

Abstract: Three patients with X-linked chronic granulomatous disease of childhood (CGD) were treated with a single daily dose of 1 g of vitamin C over a period of 8 months. Prior to this clinical trial, isolated leucocytes from patients and normals were incubated with different concentrations of ascorbate and intracellular killing activity was investigated. Contrary to previous reports, there was no improvement of polymorphonuclear (PMN) intracellular killing activity after oral administration of ascorbate, nor could in vitro ascorbate correct defective, or enhance, killing activity of normal PMNs.

Source: PubMed Central

Authors: N Foroozanfar, C F Lucas, D V Joss, K Hugh-Jones, J R Hobbs

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W42538725

FWCI: 0.153

Cites: 9

Cited by: 5

Related to: 10