Year: 2020
Type: article
Abstract: Artemisinin is a common anti-malarial drug which is primarily used for the treatment of uncomplicated Falciparum malaria. It is also reported to be used as an anti-cancer drug; hence it was worthwhile to explore its anti-mitotic effects on the onion root tip system. For this, onion bulbs were grown in tap water where they sprouted 2-3 mm roots. Their mitotic index reading at 0 hour was noted then they were transferred to the test solutions. The plasma concentration of the drug is reported to be 11mg/1000 ml; so for testing its effect 1/2plasma, plasma, 2 × plasma concentrations, 4 × plasma concentrations, and 6 × plasma concentration were taken. MI% were noted after 72 hours for 1/2plasma, plasma, 2 × plasma concentrations and after 24 hours for 4 × plasma concentrations, 6 × plasma concentrations and it was found that there was depression of the MI% at all the five concentrations when compared to their respective 0 hour readings and most of the time the depressions were statistically quite significant. Regarding the ameliorative action of Tulsi (Ocimum sanctum), tulsi extract was prepared at the rate of 15g/100ml Distilled Water. Onion bulbs that were under plasma and 2 × plasma concentrations for 96 hours were put in the extract for 72 hours. The MI% was raised in both cases but the increase was not found to be statistically significant. However, it does demonstrate the ameliorative effect of Tulsi extract on mitosis in the onion root tip system.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4255075487