Year: 1960
Type: article
Abstract: 5-(2-Thiacyclobutyl) valeric acid (III) was prepared by the reaction of alkyl 6, 8-dihaloöctanoates (IV and V) with alkali sulfide and by tosylation of mercapto-hydroxy-octanoic acids (I and VII) followed by alkali treatment. Reaction of methyl 6, 8-dichloroöctanoate (IV) with various thiolation agents invariably resulted in the formation of (III) and α-lipoic acid. It was also found that α-lipoic acid (X) or its ester (XIII and XIV) is formed by heating (III) or its ester (XI and XI) with sulfur.Using this new sulfurization reaction, 5-methyl-1, 2-dithiolane-3-valeric acid (XVI) was prepared.
Source: YAKUGAKU ZASSHI
Institution: Takeda (Japan)
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4255981925