Work

Drosophila neurotrophins reveal a common mechanism for nervous system formation

Year: 2008

Type: dataset

Abstract: Neurotrophic interactions occur in Drosophila, but to date no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival, targeting, synaptic plasticity, memory and cognition. Here we have identified a neurotrophic factor in flies, Drosophila Neurotrophin (DNT1), structurally related to all known neurotrophins and highly conserved in insects.

Source: SciVee

DOI: 10.4016/8389.01

Authors: Zhu Zhu, Pennack Pennack, McQuilton McQuilton, Forero Forero, Mizuguchi Mizuguchi, Sutcliffe Sutcliffe, Gu Gu, Fenton Hidalgo

Institutions: University of Birmingham, University of Cambridge, National Institute of Biomedical Innovation

Language: English

Topic: Neurobiology and Insect Physiology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: Wellcome Trust, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council

OpenAlex ID: W4256109986

Cites: 80

Cited by: 11

Related to: 10