Amphotericin B and Curcumin Co-Loaded Porous Microparticles as a Sustained Release System against Candida albicans
Year: 2022
Type: article
Abstract: Amphotericin B (AMB) is an antifungal drug used for serious fungal infections. However, AMB has adverse reactions such as nephrotoxicity, which limit the clinical application of AMB alone or in combination with other antifungal drugs. Nano or micro drug delivery systems (DDS) have been proven to be effective in reducing the toxic and side effects of drugs. Further, the combination of AMB with other compounds with antifungal activity, such as curcumin (CM), may enhance the synergistic effects. Herein, AMB and CM were co-loaded into porous poly (lactic-co-glycolic acid) (PLGA) microparticles (MPs) to prepare AMB/CM-PLGA MPs. The AMB/CM-PLGA MPs showed a remarkably reduced hemolysis (62.2 ± 0.6%) compared to AMB (80.9 ± 1.1%). The nephrotoxicity of AMB/CM-PLGA MPs is significantly lower than that of AMB. In vitro, AMB/CM-PLGA MPs had better inhibitory effects on the adhesion and biofilm formation of Candida albicans compared with AMB. Experiments on mice infected with C. albicans showed that AMB/CM-PLGA MPs have a better therapeutic effect than AMB in vivo. In summary, AMB/CM-PLGA MPs may be a novel and promising therapeutic candidate for fungal infection.
Source: Molecules
Authors: Baiji Xue, Yanhua Yu, Guoqiang Peng, Mengmeng Sun, Peng Lv, Xuefeng Li
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,408
Funders: Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Natural Science Foundation of China, Ministry of Education of the People's Republic of China, China Postdoctoral Science Foundation, Natural Science Foundation of Guangdong Province, People's Government of Jilin Province, Education Department of Jilin Province, Higher Education Discipline Innovation Project
Awards: G1165720675, G1179249420, G1192156788, G1193419127, G1196712463, G1422803836, G1474490597, G1638628387, G1651445226, G1986756923, G203127880, G2234530043, G2258768988, G2706927393, G2748577545, G328830202, G3315941570, G3618830191, G4005891277, G4377914187, G4547956009, G4585098152, G5016885835, G525500535, G5532619707, G575726069, G5846083336, G5978440566, G5986944380, G5993525409, G6637325458, G6767522844, G727711388, G7304702724, G7417609001, G7763763103, G7803929761, G8123612400, G8708165180, G8811922978, G8882953217, G974698630
OpenAlex ID: W4280575083