Work

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

Year: 2022

Type: article

Abstract: Due to rising rates of antifungal drug resistance and a limited armamentarium of antifungal treatments, there is a paramount need for novel antifungal drugs to treat systemic fungal infections. Calcineurin has been established as an essential and conserved virulence factor in several fungi, making it an attractive antifungal target.

Source: mBio

DOI: 10.1128/mbio.01049-22

Authors: Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman

Institutions: Duke Medical Center, Duke University, Center for Infectious Disease Research

Language: English

Topic: Fungal Infections and Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: U.S. Department of Health and Human Services, National Institutes of Health, UCB US, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G1135287008, G1580077915, G2615831811, Regulatory mechanisms governing Th17 cell effector identity and plasticity, G3367114794, G3367614517, Structure-guided development of fungal specific calcineurin inhibitors, G423459200, G5614002096, G6048608882, G7794633445, G8003535823, Structural Biological Development of Fungal-Specific Calcineurin Inhibitors, Structural Biological Development of Fungal-Specific Calcineurin Inhibitors

OpenAlex ID: W4281289403

FWCI: 3.15

Cites: 59

Cited by: 31

Related to: 10