Glucose as a risk factor for periodontitis in kidney transplantation patients
Year: 2022
Type: preprint
Study design: Observational Study
Abstract: Background: Various factors including diabetes and oxidative stress are associated with periodontal inflammation. In patients with end stage renal disease (ESRD), accumulation of uremic toxin leads to various systemic abnormalities, including cardiovascular disease, metabolic abnormalities, and infection. Even after kidney transplantation (KT), various factors are known to be associated with inflammation. Our study, therefore aimed to study risk factors associated with of periodontitis in KT patients.Methods: Patients, who visited Dongsan Hospital, Daegu, Korea, since 2018, and diagnosed of periodontal disease were selected. As of November 2021, 923 participants, with full data including hematologic factors were studied. Results: From 923 KT patients, 30 were diagnosed with periodontal disease. Fasting glucose levels were higher in patients with periodontal disease, while total bilirubin levels were lower. When divided by fasting glucose levels, high glucose level showed increase of periodontal disease with odds ratio (OR) of 1.031 (95% confidence interval (CI) 1.004-1.060). After adjusting for confounders, results were significant with OR 1.032 (95% CI 1.004-1.061). Conclusions: Our study have shown that KT patients, of whom uremic toxin clearance has been revolted, are yet at risk of periodontitis by other factors, such as high blood glucose levels.
Source: Research Square
Authors: Shin Young-Min, Kwang Ho Mun
Institutions: Keimyung University, Inje University
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4281492736