Therapeutic-Dose vs. Prophylactic-Dose Anticoagulation Therapy for Critically Ill Patients With COVID-19 in a Practice-Based Observational Study
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The potential benefit of therapeutic-dose anticoagulation for critically ill patients with coronavirus disease 2019 (COVID-19) is still controversial. METHODS AND RESULTS: In the CLOT-COVID study, 225 patients with severe COVID-19 on admission requiring mechanical ventilation or extracorporeal membrane oxygenation were divided into patients with therapeutic-dose anticoagulation (N=110) and those with prophylactic-dose anticoagulation (N=115). There was no significant difference in the incidence of thrombosis between the groups (9.1% vs. 7.8%, P=0.73). CONCLUSIONS: Among a cohort of critically ill patients with COVID-19, approximately half received therapeutic-dose anticoagulation, although it did not show a potential benefit compared with prophylactic-dose anticoagulation.
Source: Circulation Journal
Authors: Yugo Yamashita, Sen Yachi, Makoto Takeyama, Yuji Nishimoto, Ichizo Tsujino, Junichi Nakamura, Naoto Yamamoto, Hiroko Nakata, Satoshi Ikeda, Michihisa Umetsu, Shizu Aikawa, Hiroya Hayashi, Hirono Satokawa, Yoshinori Okuno, Eriko Iwata, Yoshito Ogihara, Nobutaka Ikeda, Akane Kondo, Takehisa Iwai, Norikazu Yamada, Tomohiro Ogawa, Takao Kobayashi, Makoto Mo
Institutions: Kyoto University Hospital, Japan Community Healthcare Organization, Tokyo Shinjuku Medical Center, Hyogo Prefectural Amagasaki General Medical Center, Hokkaido University Hospital, Hamamatsu Medical Center, Yokosuka General Hospital Uwamachi, Nagasaki University, Tohoku University Hospital, Tsukuba Medical Center Hospital, Osaka Metropolitan University, Fukushima Medical University, Nankai Medical Center, Mie University Hospital, Toho University Ohashi Medical Center, Shikoku Medical Center for Children and Adults, Kuwana City Medical Center, Yokohama Minami Kyosai Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funder: Fujiwara Memorial Foundation
OpenAlex ID: W4281644908