Work

Microwave-Assisted, Metal-Free, Chemoselective N-Formylation of Amines using 2-Formyl-1,3-dimethyl-1H-imidazol-3-ium Iodide and In Situ Synthesis of Benzimidazole and Isocyanides

Year: 2022

Type: article

Abstract: An efficient, environmentally benign, chemoselective, microwave-assisted N-formylation protocol of aromatic, aliphatic, alicyclic, benzylic amines, inactivated aromatic amines and sterically demanding heterocyclic amines using 2-formyl-1,3-dimethyl-1H-imidazol-3-ium iodide has been developed. This affords a series of N-substituted formamides with good to excellent yields (23 examples, 53–96% yield) and can be readily scaled. The methodology can be further extended to synthesize benzimidazole and isocyanide derivatives.

Source: SynOpen

DOI: 10.1055/s-0041-1737605

Authors: Naraganahalli R. Thimmegowda, Kanchugarakoppal S. Rangappa, Gullahalli S. Jagadeesha, Kempegowda Mantelingu

Institutions: Visvesvaraya Technological University, University of Mysore

Language: English

Topic: Microwave-Assisted Synthesis and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $340

Funder: University of Mysore