Work

The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria

Year: 2022

Type: review

Abstract: The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and unprecedented molecular structures, have prompted an intense research activity directed towards their total syntheses, analogue design, and biological evaluations for their development as new anticancer agents. Together with these biological studies in cancer research, in recent years, the bengamides have been identified as potential antibiotics by their impressive biological activities against various drug-resistant bacteria such as Mycobacterium tuberculosis and Staphylococcus aureus. This review reports on the new advances in the chemistry and biology of the bengamides during the last years, paying special attention to their development as promising new antibiotics. Thus, the evolution of the bengamides from their initial exploration as antitumor agents up to their current status as antibiotics is described in detail, highlighting the manifold value of these marine natural products as valid hits in medicinal chemistry.

Source: Marine Drugs

DOI: 10.3390/md20060373

Authors: Cristina Porras-Alcalá, Federico Moya-Utrera, Miguel García-Castro, Antonio Sánchez-Ruiz, Juan Manuel López-Romero, María Soledad Pino-González, Amelia Díaz-Morilla, Seiya Kitamura, Dennis W. Wolan, José Prados, Consolación Melguizo, Iván Cheng-Sánchez, Francisco Sarabia

Institutions: Universidad de Málaga, University of Castilla-La Mancha, Scripps Research Institute, Albert Einstein College of Medicine, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, University of Zurich

Language: English

Topic: Marine Sponges and Natural Products

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,513

Funders: Universidad de Málaga, Ministerio de Ciencia, Innovación y Universidades, Ministerio de Educación, Cultura y Deporte, Ministerio de Ciencia e Innovación, Universidad de Granada, Universidad de Castilla-La Mancha, Instituto de Salud Carlos III, National Institute of General Medical Sciences

Awards: G1033789109, G1226243589, A universal high-throughput platform to improve biological functions of small molecules, G1418277388, G1442028653, G1737404329, G1929523587, G2056892752, G2472799858, G2542942744, G27686093, G2920307980, Terapia combinada mediante el uso de nanocápsulas funcionalizadas para la eliminación selectiva de células madre tumorales de cáncer de colon, G3369737148, G342952517, G3513073766, G4006755150, G4204492740, G459231383, G4671361384, G5210404858, G5216805778, G5528145474, G5663611129, Expanding the chemical biological tools for the detection and regulation of human and bacterial proteases, G5966391260, G6313445328, G6581713424, G6649762514, G6679399986, G6768250568, G6837893198, G6909544363, G7141865944, G7533879004, G7780279885, G7955070378, G8151068533, G8569959355, G8784878964, G8896463055, G93077892

OpenAlex ID: W4281908765

FWCI: 0.289

Cites: 80

Cited by: 13

Related to: 10