Work

Low-dose metformin and PEN2-dependent lysosomal AMPK activation: benefits outnumber side effects

Year: 2022

Type: article

Abstract: Recent advances demonstrated numerous molecular mechanisms of metformin based on the dosage and duration, yet our understanding is limited. Using a photoactive metformin probe Ma et al. 1 identified presenilin enhancer 2 (PEN2) as its interaction partner and demonstrated its contribution to AMP-activated protein kinase (AMPK) activation. 1

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-022-01040-9

Authors: Longlong Liu, Pradeep Kumar Patnana, Subbaiah Chary Nimmagadda

Institution: University Hospital Münster

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,491