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Macrophage diversity in cancer revisited in the era of single-cell omics

Year: 2022
Type: review
Abstract: Tumor-associated macrophages (TAMs) have multiple potent functions in cancer and, thus, represent important therapeutic targets. These diverse functions highlight the heterogenous nature of TAMs. Recent single cell omics technologies have significantly advanced our understanding of the molecular diversity of TAMs. However, a unifying nomenclature of TAM diversity and annotation of their molecular signatures is lacking. Here, we review recent major studies of single cell transcriptome, epigenome, metabolome, and spatial omics of cancer with a specific focus on TAMs. We also propose a consensus model of TAM diversity and present avenues for future research.
DOI: 10.1016/j.it.2022.04.008
Authors: Ruo-Yu Ma, Annabel Black, Bin-Zhi Qian
Institutions: Fudan University, Edinburgh Cancer Research, University of Edinburgh, MRC Centre for Reproductive Health, Institute of Genetics and Cancer, The Queen's Medical Research Institute
Language: English
Subfield: Immunology
Open Access status: hybrid
Estimated APC paid: $6,700
Funders: Cancer Research UK, Rosetrees Trust, University of Edinburgh, National Natural Science Foundation of China, China Postdoctoral Science Foundation, Medical Research Council, European Research Council
Awards: G3691525269, G4692977525, G5831235643, G6143638457, G7784252834, G7818575306, G8461036576
OpenAlex ID: W4282943635
FWCI: 12.31
Cites: 115
Cited by: 698
Related to: 10