Year: 2022
Type: article
Study design: Observational Study
Abstract: Objective: Our purpose in this study was to evaluate whether Kirsten rat sarcoma viral oncogene (KRAS) exon-2 mutation affected 18 F-fluorodeoxyglucose (FDG) accumulation patterns, total lesion glycolysis and metabolic tumor volume in colorectal cancer.Method: This retrospective study included 52 colorectal cancer patients.Dual-time 18 F-FDG positron emission tomography/computed tomography (PET/CT) parameters such as the maximum standardized uptake values (SUV max ), tumor-to-liver parenchyma SUV max ratios (TLR), retention index (RI), metabolic tumor volumes (MTV), total lesion glycolysis (TLG) and glucose corrected-TLGs were measured.Results: There were no statistical differences in PET/CT imaging parameters between mutated and wild-type colon cancer, but RI and RI (TLR) values were statically higher in wild-type than in mutated-type.KRAS exon-2 wild-type rectal cancer patients had low MTV (p=0.044).KRAS mutation status was correlated with MTV (r=-0.277,p=0.048).ROC curves analysis showed that MTV and MTV (%) predicted KRAS exon-2 mutation status accurately.Conclusion: Although we did not find a relationship between KRAS exon-2 mutation status and increased 18 F-FDG uptake in both colon and rectal cancer patients in our study, KRAS exon-2 wild-type colon cancer patients showed interestingly increased uptake of 18 F-FDG in time.Even if we find a correlation between KRAS exon-2 mutation status and MTV, it was not very strong.
Source: Bagcilar Medical Bulletin
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4283075809