Work

Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in Picornaviruses

Year: 2022

Type: article

Abstract: Picornaviridae is a group of RNA viruses that harm both humans and livestock. 3C pro is an essential enzyme for picornavirus maturation, which makes it a promising target for antiviral drug development and a critical component for virus-like particle (VLP) production. However, the current challenge in the development of antiviral drugs and VLP vaccines includes the limited knowledge of how subsite structure determines the 3C pro cleavage pattern.

Source: Journal of Virology

DOI: 10.1128/jvi.00736-22

Authors: Kaiwen Meng, Lijie Zhang, Xiaoyin Xue, Qinghong Xue, Miao Sun, Geng Meng

Institutions: China Agricultural University, Henan University, China Institute of Veterinary Drug Control

Language: English

Topic: Enzyme Structure and Function

Subfield: Structural Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Natural Science Foundation of Hebei Province, National Key Research and Development Program of China

Awards: G7153848147, G8169108071