Serum IgG4 Concentration Is a Potential Predictive Biomarker in Glucocorticoid Treatment for Idiopathic Retroperitoneal Fibrosis
Year: 2022
Type: article
Study design: Observational Study
Abstract: Objectives: To evaluate the management and outcome of idiopathic retroperitoneal fibrosis (iRPF) in Japan, and to identify its clinical biomarker. Methods: We retrospectively analyzed 129 patients with iRPF treated between January 2008 and May 2018 at 12 university and related hospitals. Patients treated with glucocorticoid were analyzed to identify a predictive biomarker. These patients were classified into three groups according to overall effectiveness (no change: NC, complete response: CR, and partial response groups: PR), and each parameter was compared statistically. Results: Male–female ratio was 5:1, and median age at diagnosis was 69 (33–86) years. Smoking history was reported in 59.6% of the patients. As treatment, 95 patients received glucocorticoid therapy with an overall response rate of 84%. As a result, serum concentration of IgG4 was significantly decreased in NC group compared with the other two groups (56.6 mg/dL vs. 255 mg/dL, 206 mg/dL, p = 0.0059 and 0.0078). ROC analysis was performed between the nonresponder (NC) and responder groups (CR + PR) to identify the cut-off value of serum IgG4 as a predictive marker. As a result, AUC of 0.793 was confirmed. Conclusions: Pre-treatment serum IgG4 concentration may have potential as a predictive biomarker of steroid treatment.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm11123538
Authors: Shoichiro Mukai, Naotaka Sakamoto, Hiroaki Kakinoki, Tadamasa Shibuya, Ryosuke Moriya, Kiyoaki Nishihara, Mitsuru Noguchi, Toshitaka Shin, Naohiro Fujimoto, Tsukasa Igawa, Tatsu Ishii, Nobuhiro Haga, Hideki Enokida, Masatoshi Eto, Tomomi Kamba, Hideki Sakai, Seiichi Saito, Naoki Terada, Toshiyuki Kamoto
Institutions: University of Miyazaki, National Kyushu Medical Center, Saga University, Oita University, University of Occupational and Environmental Health Japan, Kurume University, Kurume University Medical Center, Fukuoka University, Kagoshima University, Kyushu University, Kumamoto University, Nagasaki University, University of the Ryukyus
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,513
OpenAlex ID: W4283207352