Work

The Current Knowledge on the Pathogenesis of Tissue and Medical Device-Related Biofilm Infections

Year: 2022

Type: article

Abstract: Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are highly tolerant to antimicrobials and escape the host immune system. Thus, the refractory nature of biofilm-related infections (BRIs) still represents a great challenge for physicians and is a serious health threat worldwide. Despite its importance, the microbiological diagnosis of a BRI is still difficult and not routinely assessed in clinical microbiology. Moreover, biofilm bacteria are up to 100-1000 times less susceptible to antibiotics than their planktonic counterpart. Consequently, conventional antibiograms might not be representative of the bacterial drug susceptibility in vivo. The timely recognition of a BRI is a crucial step to directing the most appropriate biofilm-targeted antimicrobial strategy.

Source: Microorganisms

DOI: 10.3390/microorganisms10071259

Authors: Enea Gino Di Domenico, Alessandra Oliva, María Guembe

Institutions: Sapienza University of Rome, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,303