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Local Delivery of Streptomycin in Microcontainers Facilitates Colonization of Streptomycin-Resistant Escherichia coli in the Rat Colon

Year: 2022
Type: article
Abstract: Delivery of antibiotics in microcontainer devices designed for release at specific sites of the gut represents a novel approach which might reduce the amount of antibiotic needed to obtain a local selective effect. We propose that the application of microcontainers may have the potential to open novel opportunities for antibiotic treatment of humans and animals with fewer side effects on nontarget bacterial populations. In the current study, we therefore elucidated the effects of streptomycin, delivered in microcontainers coated with pH-sensitive lids, on the selective effect on a resistant bacterium, as well as on the surrounding intestinal microbiota in rats.
DOI: 10.1128/aem.00734-22
Authors: Anders M. Torp, Khorshid Kamguyan, Juliane F. Christfort, Katja Ann Kristensen, Priscila Guerra, Noëmie Daniel, Line Hagner Nielsen, Kinga Zòr, Benoit Chassaing, Anja Boisen, Martin I. Bahl, Tine Rask Licht
Language: English
Open Access status: hybrid
Funders: Kenneth Rainin Foundation, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Novo Nordisk, Novo Nordisk Fonden, Université de Paris, European Research Council
Awards: G1963894250, G3186420570, G3765630631, G4180218856, G434337789, G4422322373, G4656594441, G4707887143, G4717050644, Université de Paris
OpenAlex ID: W4283587652
FWCI: 0.408
Cites: 33
Cited by: 4
Related to: 10