Work

Influence of 3-acetyl-5-hydroxy-2-methylindole on glioma cell proliferation and metabolism

Year: 2022

Type: article

Abstract: A 3-acetyl analogue of 5-hydroxyindole was synthesised and evaluated for its effects on rat C6 glioma cell functions. It was found that 3-acetyl-5-hydroxy-2-methylindole at 10 μmol/L led to a sharp reduction of mitochondrial membrane potential, induction of autophagy and decrease of proliferation of C6 glioma cells. The compound’s effect was comparable to that of rotenone, an inhibitor of cell respiration.

Source: Journal of the Belarusian State University Chemistry

DOI: 10.33581/2520-257x-2022-1-43-52

Authors: Jan U. Panada, Valeriya A. Klopava, Tatsiana A. Kulahava, Yaroslav V. Faletrov, Matvey S. Horetski, Nina S. Frolova, Siarhei V. Koran, Elena G. Fomina, Vladimir M. Shkumatov

Institutions: Belarusian State University, Republican Research and Practical Center for Epidemiology and Microbiology

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4283757015

FWCI:

Cites: 28

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Related to: 10