Work

A dramatic course after the resection of an SMARCA4 ‐deficient undifferentiated tumour

Year: 2022

Type: article

Abstract: Thoracic SMARCA4-deficient undifferentiated tumours are ordinarily found as a huge mass with systemic metastasis, and the prognosis is poor. The potential of immunotherapy for these unresectable tumours has been reported. An asymptomatic 68-year-old man with a smoking history had a left lung mass without distant metastasis and underwent complete resection. Two months after surgery, with no adjuvant therapy, he developed multiple distant metastases with aphasia and died 4 months after surgery. Adjuvant treatment may be necessary with immune checkpoint inhibitors, with a closer follow-up to detect recurrence without symptoms.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.1001

Authors: Takafumi Iguchi, Shinjiro Mizuguchi, Kyukwang Chung, Ryu Nakajima, Makoto Takahama

Institution: Osaka City General Hospital

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000