Work

In vitro cytotoxicity of sesquiterpene lactones isolated from Centaurea pullata L. native to Algeria

Year: 2022

Type: article

Abstract: The phytochemical investigation of the aerial parts of Centaurea pullata L. from Algeria led to the isolation and identification of ten sesquiterpene lactones. The in vitro cytotoxic and antiproliferative potential of the isolated sesquiterpene lactones was tested against fives human cell lines (i.e., DLD1, SF268, MCF7, NCI-H460 and OVCAR3) using the sulforhodamine B (SRB) assay. In total ten compounds were tested, among which the elemanolide melitensin (5) proved the most active demonstrating a growth inhibitory activity below 100 μM against three cell lines NCI-H460, MCF7 and SF268, from the five tested.

Source: Journal of Natural Product Research and Applications

DOI: 10.46325/jnpra.v1i03.29

Authors: Samah DJEDDI, Κonstantinos DIMAS2, Wissam MAZOUZ, Helen SKALTSA

Institutions: National and Kapodistrian University of Athens, Larbi Ben M'hidi University of Oum El Bouaghi

Language: English

Topic: Sesquiterpenes and Asteraceae Studies

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4284893312

FWCI:

Cites: 9

Cited by:

Related to: 10