Evaluation of biochemical profile based on vitamin D status and severity of disease in stage 3 to stage 5 chronic kidney disease
Year: 2022
Type: article
Study design: Observational Study
Abstract: In chronic kidney disease major cause of mortality is cardiovascular disease.This mortality of cardiovascular is more in as disease advances.In CKD, there is decreased vitamin D and hyperphosphataemia and development of end-stage renal disease.Hence, aim of present study was asses the relationship between bone mineral parameters and atherogenic index of plasma based on vitamin D status.The study contains 45 control group and 135 will be CKD individuals with stage 3 to stage 5, each stage consists of 45 each.In all the subjects atherogenic index of plasma, blood urea, creatinine, serum calcium, serum phosphorus vitamin D and parathyroid hormone are estimated.The mean serum calcium and vitamin D were decreased in CKD whereas phosphorus, magnesium and parathyroid hormone (PTH) were increased compared with control and it is statistically significant.There was positive correlation glomerular filtration rate (GFR) with calcium, vitamin D. Whereas, GFR withatherogenic index of plasma (AIP), phosphorous, magnesium; PTH was shown negative correlation and it is statistically significant.There was no significance difference of GFR, AIP, phosphorus, magnesium and PTH between Group 1 (vitamin D deficiency) and Group 2 (vitamin D insufficient).Whereas, Group 1 Vs Group 3 (vitamin D sufficient) and Group2 vs. Group 3 shown a statistically significance difference.The assessment of these parameters will be helpful in prevent of future risk and also helpful in better life and outcome from cardiovascular risk in chronic kidney disease.
Authors: D.S.S.K. Raju, G.S.R. Kedari
Institution: Saveetha University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4284962425