The Inhibition Potential of Thai-colored Rice Extract Against Diabetes Related-enzymes and Melanin Biosynthesis-related Enzyme
Year: 2022
Type: article
Abstract: Thailand has both colored and non-colored rice.Thai people use rice both for consumption and health treatment.This study investigates the phytochemical profile, α-glucosidase and tyrosinase inhibitory activity of water extract, ethanol extract, and methanol extract of 7 cultivars of Thaicolored rice.The results reveal that 7 cultivars of Thai-colored rice had composed of flavonoids, reducing sugar, saponins, and terpenoids.The highest potency against a-glucosidase activity was obtained from rice cultivar 6 of methanol extract with the IC50 value of 1.06 ± 0.13 µg.ml -1 , approximately 175-times more efficient than commercial drug acarbose.Moreover, methanol extract of all rice cultivars seems to have higher αglucosidase inhibitory activity than other solvent extract and acarbose.In comparison, water extract of all rice cultivars had higher tyrosinase inhibitory activity than other solvents.The highest tyrosinase inhibitory efficiency was also obtained from rice cultivar 6 of water extract with the IC50 values of 10.93 ± 3.41 µg.ml -1 .Our results indicated that the highpolarity solvent can extract the bioactive compounds from plants with a high potency of α-glucosidase and tyrosinase inhibitory activity.The results also suggested that rice especially colored rice had contained the bio-active compounds which related with α-glucosidase and tyrosinase inhibitory activity.
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4285099375