Evaluation of the Potential of Malignant Transformation in Oral Lichen Planus by Immunohistochemistry
Year: 2022
Type: article
Study design: Observational Study
Abstract: Malignant transformation is suggested to be a consequence of alterations in cell cycle control, and this potential of oral lichen planus (OLP) is still controversial.The aim of this study was to evaluate the malignant transformation of OLP comparing with normal oral mucosa (NOM) and oral squamous cell carcinoma (OSCC) by immunohistochemistry. METHODS Bcl-2 and p53 expressions were determined by immunohistochemistry in 100 oral mucosal biopsies including NOM (n=20), OLP (n=40) and OSCC (n=40). RESULTSThere were no significant differences in p53 and bcl-2 expressions between OLP and OSCC cases.However, p53 expression was higher in OLP and OSCC compared to normal epithelium (p<0.05). CONCLUSIONThe results of this study suggest that changes in proteins responsible for cell proliferation and apoptosis may play a role in the possible malignant transformation of OLP, but other molecular mechanisms involved in the cell cycle may also have an impact on the development of oral carcinogenesis.Therefore, long-term follow-up of patients with OLP with an accurate final diagnosis to be made by clinicopathological correlation, further research is needed to identify markers and independent risk factors that predict malignant transformation of OLP.
Source: Turkish Journal of Oncology
Author: nihan aksakallı
Institution: Istanbul University
Language: English
Subfield: General Dentistry
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4285250040