Genetic Factors of Preposition to Bone Fractures in Athletes
Year: 2021
Type: conference-paper
Study design: Observational Study
Abstract: A retrospective study was carried out, which included professional athletes. The athletes were divided into two groups, depending on the presence of bone fractures in the anamnesis. DNA isolated from the buccal epithelium was used as a biological material. Two informative genetic markers were identified that statistically increase the risk of stress fractures in the study group. The most significant differences between the studied groups in the distribution of genotype and allele frequencies were found for the rs7975232 variants of the VDR gene and rs42517 of the COL1A2 gene. The results indicate the important role of these loci in the pathogenesis of fractures. Identification of unfavorable variants of allelic combinations makes it possible to assess the individual risk of bone fractures.
Authors: T. V. Makey, P. M. Marozik
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4285465352