Year: 2022
Type: review
Abstract: Multicellularity was a watershed development in evolution. However, it also meant that individual cells could escape regulatory mechanisms that restrict proliferation at a severe cost to the organism: cancer. From the standpoint of cellular organization, evolutionary complexity scales to organize different molecules within the intracellular milieu. The recent realization that many biomolecules can "phase-separate" into membraneless organelles, reorganizing cellular biochemistry in space and time, has led to an explosion of research activity in this area. In this review, we explore mechanistic connections between phase separation and cancer-associated processes and emerging examples of how these become deranged in malignancy. SIGNIFICANCE: One of the fundamental functions of phase separation is to rapidly and dynamically respond to environmental perturbations. Importantly, these changes often lead to alterations in cancer-relevant pathways and processes. This review covers recent advances in the field, including emerging principles and mechanisms of phase separation in cancer.
Source: Cancer Discovery
Institutions: University of Michigan, Cleveland Clinic, Stanford University, The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston, Oregon Health & Science University, OHSU Knight Cancer Institute, The University of Texas at Austin, Stanford Medicine, Baylor College of Medicine
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Funders: National Science Foundation, U.S. Department of Defense, David and Lucile Packard Foundation, Howard Hughes Medical Institute, Gordon and Betty Moore Foundation, Breast Cancer Research Foundation, Damon Runyon Cancer Research Foundation, Research Corporation for Science Advancement, Cancer Prevention and Research Institute of Texas, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute, National Institute of General Medical Sciences, National Center for Advancing Translational Sciences, DOD Peer Reviewed Cancer Research Program
Awards: Determining the Immunological Consequences of DNA Replication Stress Response Defects in Renal Cells Carcinoma to Improve Immunotherapy Outcomes, Center for Clinical and Translational Sciences (CCTS), U.T. M. D. Anderson Cancer Center SPORE in Ovarian Cancer, i-SINFOP: Integrative Systems-scale Interrogation of Neomorphic Fusion OncoProteins, G1767774043, Network-based Framework to Decode Novel âÃÂÃÂGain-of-FunctionâÃÂàMutations and their Mechanistic Roles in General Human Diseases, G2065979237, Epigenetics in the extreme - investigating heritability driven by disordered RNA binding proteins in development and cancer, G2293521345, G2518634775, Data Science and Informatics Core for Cancer Research, G368460402, G4119534169, Protein-based Molecular Memories in Gene Regulation, Disease, and Development, G5850682332, Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancer, CAREER: Investigation of a Prion-based Metabolic Switch Driven by Cross-kingdom Chemical Communication, Recruitment of First-Time, Tenure-Track Faculty Members, G6453487649, G6581751903, G6671297155, Deciphering Functional Consequences of Specific and Combinatorial Mutations in Protein Interaction Networks, G8166743225, G81772119, G8280086477
OpenAlex ID: W4286221663