Work

Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant

Year: 2022

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.2c00922

Authors: Shan Li, Hongfei Si, Xiaojuan Song, Chong Lei, Xiaoqiang He, Jie Wang, Yiling Liu, Yang Zhou, Jian-Guo Song, Lijie Peng, Xia Tang, Shingpan Chan, Xiaomei Ren, Zhengchao Tu, Zhengqiu Li, Zhen Wang, Zhang Zhang, Ke Ding

Institutions: Jinan University, Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health, Shanghai Institute of Organic Chemistry

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Ministry of Science and Technology of the People's Republic of China, Government of Guangdong Province, Shenzhen Bay Laboratory

Awards: G112232999, G2213517137, G2765715623, G3147855717, G3295225175, G455593815, G6087333360, G8089501462, G8124966002

OpenAlex ID: W4286503785

FWCI: 0.842

Cites: 36

Cited by: 15

Related to: 10