Work

RNA m6A modification orchestrates the rhythm of immune cell development from hematopoietic stem cells to T and B cells

Year: 2022

Type: review

Abstract: RNA, one of the major building blocks of the cell, participates in many essential life processes. RNA stability is well-established to be closely related to various RNA modifications. To date, hundreds of different RNA modifications have been identified. N6-methyladenosine (m6A) is one of the most important RNA modifications in mammalian cells. An increasing body of evidence from recently published studies suggests that m6A modification is a novel immune system regulator of the generation and differentiation of hematopoietic stem cells (HSCs) and immune cells. In this review, we introduce the process and relevant regulatory mechanisms of m6A modification; summarize recent findings of m6A in controlling HSC generation and self-renewal, and the development and differentiation of T and B lymphocytes from HSCs; and discuss the potential mechanisms involved.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2022.839291

Authors: Chuanxiang Zhao, Guoying Xu, Xiaoxian Zhang, Yunfeng Ye, Weili Cai, Qixiang Shao

Institutions: Jiangsu College of Nursing, Jiangsu University

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,950