Work

Urinary microbiome profile in men with genitourinary malignancies

Year: 2022

Type: article

Abstract: PURPOSE: Recent advances in molecular biology technology have allowed identification of microbial communities in the urinary tract, and urinary microbiome is associated with various urological diseases. In this study, we aimed to characterize the urinary microbiome of genitourinary malignancies. MATERIALS AND METHODS: Metagenomic analysis of urinary DNA was performed in 85 patients including 30 with bladder cancer (BC), 27 with prostate cancer (PC), 12 with renal cancer (RC), and 16 with non-cancer (NC). 16S rRNA gene sequencing was conducted after amplification of the V3-V4 region. RESULTS: were significantly increased in both PC and RC. CONCLUSIONS: Urinary microbiome composition was different depending on the type of genitourinary malignancies, and we identified bacteria that are significantly associated with each type of malignancy. Specifically, several bacterial species were associated both PC and RC, suggesting that PC and RC share a similar pathogenesis-related urinary microbiome.

Source: Korean journal of urology

DOI: 10.4111/icu.20220124

Authors: Hyun Kyu Ahn, Kwangmin Kim, Junhyung Park, Kwang Hyun Kim

Institutions: Ewha Womans University Seoul Hospital, 3BIGS (South Korea)

Language: English

Topic: Urinary Tract Infections Management

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Research Foundation of Korea