Diabetes, cognitive decline, and mild cognitive impairment among diverse Hispanics/ Latinos: Study of Latinos–Investigation of neurocognitive aging results (HCHS/SOL)
Year: 2020
Type: article
Abstract: OBJECTIVE Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos. RESEARCH DESIGN AND METHODS The Study of Latinos–Investigation of Neurocognitive Aging (SOL-INCA) is an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/ SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability-sampled (i.e., representative of targeted populations), and prospective cohort study. Between 2016 and 2018, SOL-INCA enrolled diverse Hispanics/Latinos aged ‡50 years (n 5 6,377). Global cognitive decline and mild cognitive impairment (MCI) were the primary outcomes. RESULTS Prevalent diabetes at visit 1, but not incident diabetes at visit 2, was associated with significantly steeper global cognitive decline (bGC 5 20.16 [95% CI 20.25; 20.07]; P < 0.001), domain-specific cognitive decline, and higher odds of MCI (odds ratio 1.74 [95% CI 1.34; 2.26]; P < 0.001) compared with no diabetes in age- and sex-adjusted models. CONCLUSIONS Diabetes was associated with cognitive decline and increased MCI prevalence among diverse Hispanics/Latinos, primarily among those with prevalent diabetes at visit 1. Our findings suggest that significant cognitive decline and MCI may be considered additional disease complications of diabetes among diverse middle-aged and older Hispanics/Latinos.
DOI: 10.17615/jzsr-ew47
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Office of Dietary Supplements, University of Miami, Northwestern University, San Diego State University, Institut National Du Cancer, National Institutes of Health, Gillings School of Public Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1042216835, G1081972346, G1301356587, G1312369436, G1455175283, G1587824183, MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos, G1917633662, G2135211244, G2135293100, G2466919156, G2501967490, G2575730562, G2644289446, G2866617920, G3062787641, G3677686024, G3722034730, G3838006641, G3952816605, G4121762840, G4421869008, G4552920371, G4860668542, G4989378220, G528357465, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G6156511736, Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse Latinos, G6585687856, G6744188800, G6914194341, G7057037114, G7203655167, G7239480477, G7272721675, G7278742613, G7408420985, G7513901258, G7678550560, Exploring Sleep in Neurocognitive Aging and Alzheimer's Research (eSANAR), G8102260223, G820454163, G8386326007, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, G8932431361, G9000199330, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, San Diego Alzheimer's Disease Resource Center for Minority Aging Research (San Diego AD-RCMAR)
OpenAlex ID: W4287953643