Efficacy of subthreshold trabeculoplasty with micropulse laser in the treatment of primary open angle glaucoma
Year: 2022
Type: preprint
Study design: Clinical Trial
Abstract: Purpose To report the results of subthreshold micropulse laser trabeculoplasty (MLT) in a consecutive series of patients, affected by primary open angle glaucoma (POAG). Methods In this single-center, one-arm, prospective study conducted on sixty-eight patients (112 eyes) affected by POAG, who underwent 360° 577-nm MLT. Follow-up consultations were scheduled at 1, 6, 12, 18 and 24 months. At baseline and at each consultation after MLT, data were collected on IOP, best corrected visual acuity, local and systemic side effects, number of eye-drops in use. Results One-hundred and twelve eyes of 68 patients were enrolled. Mean age was 57.68 ± 8.0 years, mean baseline IOP was 18.4 ± 5.2 mmHg with 1.43 ± 0.85 glaucoma medications. Treatment with MLT resulted in significantly lower IOP at both 1 month (18.4 ± 5.2mmHg, p = 0.045) and 24 months (18.4 ± 5.2 mmHg; p = 0.046) compared to baseline. No statistically significant difference was found between IOP at 1 month and at 12 months and between IOP at 1 month and at 24 months after treatment (p > 0.05). A low rate of retreatments was observed, mostly performed after 18 months from baseline. Most of the eyes were free of additional medical therapy at 12 months (88.9%) and 24 months (94.3%). No local or systemic side effects during or after MLT were reported. Conclusion This is the first prospective study to report long-term outcomes of MLT in POAG. MLT is safe and effective with an efficacy achieved within the first month and maintained after 2 years of treatment.
Source: Research Square
Institution: University of Padua
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4288037481