Efficacy of fractional carbon dioxide laser (FCO2) with intralesional 5-fluorouracil (5-FU) in the treatment of keloids
Year: 2021
Type: article
Study design: Clinical Trial
Abstract: CONTEXT: Managing keloids remains a challenge in clinical practice. Many therapeutic options are available, but none is universally accepted or without recurrence. Therefore, an effort is required to choose the treatment with maximal outcomes. AIMS: ) laser and intralesional 5-fluorouracil (5-FU) for the treatment of keloids. MATERIALS AND METHODS: /keloid of 5-FU (50 mg/mL) intralesionally, following irradiation, at identical time points. The primary outcome evaluated was the clinical response concerning height, pliability, vascularity, and pigmentation, using the Vancouver Score Scale (VSS). Adverse reactions and recurrences were recorded as secondary outcomes. RESULTS: = 11) achieving an excellent result. Adverse reactions included post-inflammatory hyperpigmentation in four patients and ulceration in two. Recurrences were reported in 21% of the patients who responded well. CONCLUSIONS: laser and intralesional 5-FU showed a promising effect in the treatment of resistant keloids, with an acceptable safety profile and low recurrence rate.
Author: NabeelKadhim Alhamzawi
Institution: Al-Diwaniyah Teaching Hospital
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4288065708