Neurological manifestations by sex and age group in COVID-19 inhospital patients
Year: 2022
Type: article
Study design: Observational Study
Abstract: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p < 0.001; OR 1.36, 95% confidence interval [CI] 1.22–1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20–0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18–39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06–1.07; 0.7% vs. 1.7%, p = 0.002, OR 1.01, 95% CI 1.00–1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02–1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98–0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98–0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98–0.99) decreased (p < 0.001 for all). Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures.
Source: eNeurologicalSci
Authors: Daniella Nunes Pereira, Maria Aparecida Camargos Bicalho, Alzira de Oliveira Jorge, Angélica Gomides dos Reis Gomes, Alexandre Vargas Schwarzbold, Anna Luiza Homan Araújo, Christiane Corrêa Rodrigues Cimini, Daniela Ponce, Danyelle Romana Alves Rios, Genna Maira Santos Grizende, Euler Roberto Fernandes Manenti, Fernando Anschau, Fernando Graça Aranha, Frederico Bartolazzi, Joanna d'Arc Lyra Batista, Julia Teixeira Tupinambás, Karen Brasil Ruschel, Maria Angélica Pires Ferreira, Pedro Gibson Paraíso, Silvia Ferreira Araújo, Antonio Lucio Teixeira, Milena Soriano Marcolino
Institutions: Universidade Federal de Minas Gerais, Fundação Hospitalar do Estado de Minas Gerais, Hospital Risoleta Tolentino Neves, Mater Dei Hospital, Universidade Federal de Santa Maria, Hospital Universitário de Santa Maria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Federal University of São João del-Rei, Grupo Santa Casa de Belo Horizonte, Hospital Mãe de Deus, Hospital Nossa Senhora da Conceição, Grupo Hospitalar Conceição, Universidade Federal da Fronteira Sul, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, The University of Texas Health Science Center at Houston
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,680
OpenAlex ID: W4288808564