Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)
Year: 2022
Type: review
Study design: Observational Study
Abstract: AIM: Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. MATERIAL AND METHODS: Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. RESULTS: Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36-1.60; P < 0.001), and of lung (SIR 2.22, 95% CI 1.77-2.73; P < 0.001), breast (SIR 1.31, 95% CI 1.10-1.54; P = 0.003), and hematological (SIR 2.03, 95% CI 1.52-2.62; P < 0.001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1.22, 95% CI 1.01-1.03; P < 0.001), the presence of primary biliary cholangitis (OR 2.35, 95% CI 1.18-4.68; P = 0.015) and forced vital capacity <70% (OR 1.8, 95% CI 1.24-2.70; P = 0.002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0.66, 95% CI 0.45-0.97; P = 0.036). CONCLUSIONS: Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk.
Source: Autoimmunity Reviews
Authors: Cristina Carbonell, Miguel Marcos, Alfredo Guillén-del-Castillo, Manuel Rubio-Rivas, Ana Argibay, Adela Marín-Ballvé, Ignasi Rodríguez-Pintó, Maria Baldà-Masmiquel, Eduardo Callejas-Moraga, Dolores Colunga, Luis Sáez-Comet, Cristina González-Echávarri, Norberto Ortego-Centeno, Begoña Marí-Alfonso, José-Antonio Vargas-Hitos, José-Antonio Todolí-Parra, Luis Trapiella, María-Teresa Herranz-Marín, Mayka Freire, Antoni Castro-Salomó, Isabel Perales-Fraile, Ana-Belén Madroñero-Vuelta, María-Esther Sánchez-García, Manuel Ruiz-Muñoz, Andrés González-García, Jorge Sánchez-Redondo, Gloria de-la-Red-Bellvis, Alejandra Fernández-Luque, Alberto Muela-Molinero, Gema-María Lledó, Carles Tolosa-Vilella, Vicent Fonollosa-Pla, Antonio-Javier Chamorro, Carmen-Pilar Simeón-Aznar
Institutions: Universidad de Salamanca, Instituto de Investigación Biomédica de Salamanca, Vall d'Hebron Hospital Universitari, Bellvitge University Hospital, Institut d'Investigació Biomédica de Bellvitge, University Hospital Complex Of Vigo, Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria Aragón, University Hospital Mútua de Terrassa, Corporació Sanitària Parc Taulí, Hospital Universitario Central de Asturias, Hospital Universitario Miguel Servet, University of the Basque Country, BioCruces Health research Institute, Hospital de Cruces, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Hospital Universitario Virgen de las Nieves, Hospital Universitari i Politècnic La Fe, Hospital General Universitario Morales Meseguer, Complejo Hospitalario Universitario de Santiago, Hospital Universitari Sant Joan de Reus, Hospital Universitario Rey Juan Carlos, Hospital General San Jorge, Hospital Universitario de Valme, Hospital Universitario Fundación Alcorcón, Hospital Universitario Ramón y Cajal, Hospital Universitario de Móstoles, Complejo Asistencial Universitario de León, Hospital Clínic de Barcelona
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
OpenAlex ID: W4289527477