European Reference Network for Rare Vascular Diseases (VASCERN): When and how to use intravenous bevacizumab in Hereditary Haemorrhagic Telangiectasia (HHT)?
Year: 2022
Type: article
Abstract: Hereditary haemorrhagic telangiectasia (HHT) is a rare vascular multisystemic disease that leads to epistaxis, anaemia due to blood loss, and arteriovenous malformations (AVMs) in organs such as the lungs, liver and brain. HHT prevalence is estimated at 1/6000, i.e. around 85,000 European citizens, and is served by the European Reference Network for Rare Multisystemic Vascular Diseases (VASCERN). HHT treatments depend on clinical manifestations, and span multiple different medical, surgical and interventional disciplines. Separate to local treatments in the nose, in severe settings, intravenous bevacizumab has been proposed as treatment option, and the purpose of the current article is to assess the use of intravenous bevacizumab in patients with HHT in 2022 according to available data.
Authors: Sophie Dupuis-Girod, Claire L. Shovlin, Anette D. Kjeldsen, Hans-Jurgen Mager, Carlo Sabba, Freya Droege, Anne-Emmanuelle Fargeton, Annette D. Fialla, Silvia Gandolfi, Ruben Hermann, Gennaro M. Lenato, Guido Manfredi, Marco C. Post, Catherine Rennie, Patrizia Suppressa, Ulrich Sure, Claudia Crocione, Ria Blom, Luisa Maria Botella, Fernando Brocca, Caroline Coxall, Karen T. Druckman, Didier Erasme, Paolo Federici, Christina Grabowski, Mildred Lundgren, Tone Søderman, Dara Woods, Elisabetta Buscarini
Institutions: Inserm, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, CEA Grenoble, Hospices Civils de Lyon, National Health Service, Imperial College Healthcare NHS Trust, Imperial College London, University of Southern Denmark, Odense University Hospital, St. Antonius Ziekenhuis, University of Bari Aldo Moro, Essen University Hospital, Azienda Ospedaliera Ospedale Maggiore, University Medical Center Utrecht
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Awards: G1327514506, G3161585316
OpenAlex ID: W4289878359